RUNX1T1 Antilichaam - middengebied: HRP (ARP33996 T100-HRP)

Runt-related transcription factor 1; translocated to, 1 (cyclin D-related)

CDR, ETO, MTG8, AML1T1, ZMYND2, CBFA2T1, AML1-MTG8

862

Q06455

NP_783554

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

The immunogen is a synthetic peptide directed towards the middle region of human RUNX1T1

RUNX1T1 is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t (8;21) (q22; q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation.

EPS8; NECAB2; ABI3; GSE1; MID2; SPRY2; HOMER3; LPXN; ZMYM4; STX11; MEOX2; CCDC36; TRIM42; SPERT; CREB3L1; LZTS2; EFHC2; CPSF7; C19orf57; PRDM14; CBFA2T2; NCOR1; UBQLN4; ATN1; BCL6; ETS1; RUNX1; DNMT1; SPEN; RBPJ; UBE2E2; UBC; TRIM33; HDAC1; NCOR2; SIN3A

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

There is BioGPS gene expression data showing that RUNX1T1 is expressed in HepG2 RUNX1T1 is supported by BioGPS gene expression data to be expressed in 721_B

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

68kDa

Lausen, J., et al., (2004) J. Biol. Chem. 279 (47), 49281-49288

Wet Ice

604

RUNX1T1

RUNX1T1

Rabbit

Protein CBFA2T1

NM_175636

LHSEHPSKRPCTISPGQRYSPNNGLSYQPNGLPHPTPPPPQHYRLDDMAI