RUSC1 Antilichaam

RUSC1 Antibody: RUSC1, also known as NESCA, shares with the related protein RUSC2 a common domain structure of RUN, leucine zipper and SH3 domain in addition to over 30% amino acid identity. RUSC1 is an adapter protein that can bind to the TrkA receptor and is necessary in the NGF-induced neurite growth of PC12 cells. RUSC1 has also been shown to interact with Iκ B kinase- (IKK-) gamma, the regulatory subunit of the IKK complex that is required for NF-κ B activation in many signaling pathways such as TNF-R or the TLR pathways. RUSC1 can also bind to the E3 ubiquitin ligase TRAF6, which then catalyzes RUSC1 polyubiquitination. Since overexpression of RUSC1 strongly inhibits TRAF6-mediated polyubiquitination of IKK-gamma, RUSC1 may be a link in the IKK-gamma-mediated NF-κ B activation pathway.

23623

Q9BVN2

NP_001098673

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Innate Immunity

RUSC1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1288 - A20 Cell Lysate

1 mg/mL

RUSC1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

RUSC1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

RUSC1

RUN and SH3 domain containing 1

Homo sapiens

Matsuda S, Miyazaki K, Ichigotani Y, et al. Molecular cloning and characterization of a novel human gene (NESCA) which encodes a putative adapter protein containing SH3. Biochim. Biophys. Acta2000; 1491:321-6.

Katoh M and Katoh M. Characterization of RUSC1 and RUSC2 genes in silico. Oncol. Rep.2004; 12:933-8.

MacDonald JI, Kubu CJ, and Meakin SO. Nesca, a novel adapter, translocates to the nuclear envelope and regulates neurotrophin-induced neurite outgrowth. J. Cell Biol.2004; 164:851-62.

Napolitano G, Mirra S, Monfregola J, et al. NESCA: a new NEMO/IKKgamma and TRAF6 interacting protein. J. Cell. Phys.2009; 220:410-7.

RUSC1 Antibody: NESCA, NESCA, RUN and SH3 domain-containing protein 1, New molecule containing SH3 at the carboxy-terminus, Nesca

ELISA, WB

157412245

Liquid