RWDD3 Antilichaam

RWDD3 Antibody: RWDD3 (RSUME), a small RWD-containing protein, has a central role in sumoylation by enhancing SUMO conjugation in the regulatory network of immune-inflammatory signals. RWDD3 increases Iκ Beta sumoylation and stability. In addition, RWDD3 inhibits TNF-α -induced kappaB-LUC (Luciferase) reporter activity, showing the functional consequence of Iκ Beta increased stability. RSUME-enhanced sumoylation of Iκ Beta leads to the inhibition of NF-κ Beta activity on two well-known inflammatory genes, IL-8 and cyclooxygenase-2 (Cox-2) and therefore may also favor anti-inflammatory pathways. Expression of RWDD3 was induced under hypoxic conditions and it has a potential role during vascularization. Both BMP-4 and RWDD3 may be interesting targets for inhibiting steps involved in pituitary tumorigenesis.

25950

Q9Y3V2

NP_056300

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Innate Immunity

RWDD3 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1465 - Rat Kidney Tissue Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (93%)

RWDD3 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

RWDD3 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

RWDD3

RWD domain containing 3

Homo sapiens

Carbia-Nagashima A, Gerez J, Perez-Castro C, et al. RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1alpha during hypoxia. Cell2007; 131:309-23.

Liberman AC, Druker J, Garcia FA, et al. Intracellular molecular signaling. Basis for specificity to glucocorticoid anti-inflammatory actions. Ann. NY Acad. Sci.2009; 1153:6-13.

Giacomini D, Haedo M, Gerez J, et al. Differential gene expression in models of pituitary prolactin-producing tumoral cells. Horm. Res.2009; 71 Suppl 2:88-94.

RWDD3 Antibody: RSUME, RSUME, RWD domain-containing protein 3, RWD-containing sumoylation enhancer

ELISA, WB

153252154

Liquid