(RXR) 4XB (TFA)

(RXR) 4XB TFA is a cell-penetrating peptide, that binds the phosphorodiamidate morpholino oligomers (PMOs), forms peptide-conjugated PMOs (PPMOs), and improves the delivery of PMO into bacterial cells. (RXR) 4XB TFA-PMO conjugate prevents the formation of biofilms, inhibits Pseudomonas aeruginosa with MIC50 of 0.5 to 16 μM, and reduces the bacterial burden in mouse acute pneumonia models[1].

12352209

Bacterial

Anti-infection

Infection

96.56

N=C(NCCC[C@@H](C(NCCCCCC(N[C@H](C(N[C@H](C(NCCCCCC(N[C@H](C(N[C@H](C(NCCCCCC(N[C@H](C(N[C@H](C(NCCCCCC(N[C@H](C(NCCCCCC(NCCC(O)=O)=O)=O)CCCNC(N)=N)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)=O)N)N.OC(C(F)(F)F)=O.[x]

C81H158N38O15.xC2HF3O2

1904.37 (free base)

[1]Howard JJ, et al., Inhibition of Pseudomonas aeruginosa by Peptide-Conjugated Phosphorodiamidate Morpholino Oligomers. Antimicrob Agents Chemother. 2017 Mar 24;61 (4) :e01938-16.

Blue Ice

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

http://file.medchemexpress.com/batch_PDF/HY-P10559A/RXR-4XB-TFA-SDS-MedChemExpress.pdf

Peptides

No Development Reported