S- (+) -Ketoprofen-d3
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
S- (+) -Ketoprofen-d3 ((S) -Ketoprofen-d3) is deuterium labeled S- (+) -Ketoprofen. S- (+) -Ketoprofen is a potent inhibitor of both COX-1 and COX-2 with IC50s of 1.9 and 27 nM, respectively.
2747914-77-6
(S) -Ketoprofen-d3; Dexketoprofen-d3
12352005
COX; Isotope-Labeled Compounds
Immunology/Inflammation; Others
COVID-19-immunoregulation
Inflammation/Immunology
O=C(C1=CC=CC=C1)C2=CC([C@H](C([2H])([2H])[2H])C(O)=O)=CC=C2
C16H11D3O3
257.30
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Palomer A, et al. Modeling cyclooxygenase inhibition. Implication of active site hydration on the selectivity ofketoprofen analogues. J Med Chem. 2000 Jun 1;43 (11) :2280-4.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-B2137S/
Isotope-Labeled Compounds
No Development Reported
Beschrijving
S- (+) -Ketoprofen-d3 ((S) -Ketoprofen-d3) is deuterium labeled S- (+) -Ketoprofen. S- (+) -Ketoprofen is a potent inhibitor of both COX-1 and COX-2 with IC50s
Specificaties
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