(S) -Tenacissoside F

(S) -Tenacissoside F (Compound P20) is a polyoxypregnane compound found in Marsdenia tenacissima. (S) -Tenacissoside F can inhibit the drug efflux activity mediated by P-glycoprotein (P-gp/ABCB1) and reverse multidrug resistance. (S) -Tenacissoside F can be used for the research of cancer, such as colon cancer[1].

928151-78-4

12352005

P-glycoprotein

Membrane Transporter/Ion Channel

Cancer

C[C@@]12[C@]3(CC[C@H]2C(C)=O)[C@]4([C@@]([C@@H]([C@H]1O)O)([H])[C@@]5([C@@](C[C@H](CC5)O[C@H]6C[C@H]([C@@H]([C@H](O6)C)O[C@H]7[C@@H]([C@@H]([C@@H]([C@H](O7)C)O)OC)O)OC)([H])CC4)C)O3

C35H56O12

668.81

[1]To KKW, et al. Reversal of multidrug resistance by Marsdenia tenacissima and its main active ingredients polyoxypregnanes. J Ethnopharmacol. 2017 May 5;203:110-119.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N16577/

Natural Products

No Development Reported