(S) -Velpatasvir-13c, d3

(S) -Velpatasvir-13C, d3 ((S) -GS-5816-13C, d3) is 13C labeled Velpatasvir. Velpatasvir (VEL, GS-5816) is a novel pan-genotypic hepatitis C virus (HCV) nonstructural protein 5A (NS5A) inhibitor with activity against genotype 1 (GT1) to GT6 HCV replicons. Velpatasvir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 2.16 μM[2].

(S) -GS-5816-13c, d3

12352005

HCV; Isotope-Labeled Compounds; SARS-CoV

Anti-infection; Others

COVID-19-anti-virus

Cancer; Infection; Inflammation/Immunology

O=C(N[C@H](C(N1[C@@H](CC[C@@H]1C)C2=NC3=CC=C4C=C5C(OCC6=C5C=CC(C7=CN=C(N7)[C@H]8N(C[C@H](C8)COC)C([C@@H](C9=CC=CC=C9)NC(O[13C]([2H])([2H])[2H])=O)=O)=C6)=CC4=C3N2)=O)C(C)C)OC

C48 13CH51D3N8O8

887.01

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Yasmeen S, et al. An insight into the hepatoprotective role of Velpatasvir and Sofosbuvir per se and in combination against carbon tetrachloride-induced hepatic fibrosis in rats. Environ Sci Pollut Res Int. 2023 Sep;30 (42) :95660-95672.|[3]Qi Sun, et al. Bardoxolone and bardoxolone methyl, two Nrf2 activators in clinical trials, inhibit SARS-CoV-2 replication and its 3C-like protease. Signal Transduct Target Ther. 2021 May 29;6 (1) :212.|[4]Lawitz EJ et al. Clinical Resistance to Velpatasvir (GS-5816), a Novel Pan-Genotypic Inhibitor of the Hepatitis C Virus NS5A Protein. Antimicrob Agents Chemother. 2016 Aug 22;60 (9) :5368-78.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W749691/

Isotope-Labeled Compounds

No Development Reported