S100A Antilichaam [2C8B8 / 2C8E8]

S100 calcium binding protein A1 (S100-alpha/ S100A1), The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies.

6271

P23297

P23297

Human

Ni-NTA purified truncated recombinant S100A expressed in E. Coli strain BL21 (DE3) .

2C8B8 / 2C8E8

Unconjugated

Primary Antibodies

Other

Antibody is purified by protein A affinity chromatography.

Batch dependent

Ascitic fluid containing 0.03% sodium azide.

None

Blue Ice

S100A monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG1

S100A1

S100 calcium binding protein A1

Homo sapiens

Koenig A, Wojcieszyn J, Weeks BR, et al. Vet Pathol. 2001;38 (4) :427-35.

Hoyaux D, Decaestecker C, Heizmann CW, et al. Brain Res. 2000;867 (1-2) :280-8.

Pingerelli PL, Mizukami H, Wagner AS, et al. J Protein Chem. 1990;9 (2) :169-75.

S100A, S-100 protein alpha chainS100, S100A, S100-alpha

ELISA

134136