S100A12 Antilichaam

S100 calcium-binding protein A12 (S100A12) is a protein that in humans is encoded by the S100A12 gene. The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. The protein includes an antimicrobial peptide which has antibacterial activity.

Immunohistochemistry (FFPE) : 2-5 µg/mL

P80511

Human

A synthetic peptide from the C-terminus of human S100A12 was used as the immunogen for the S100A12 antibody.

IHC-P

Antigen affinity chromatography

Antigen affinity purified

Lyophilized from 1X PBS with 2% Trehalose

This S100A12 antibody is available for research use only.

After reconstitution, the S100A12 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

0.5 mg/mL if reconstituted with 0.2ml sterile DI water

Optimal dilution of the S100A12 antibody should be determined by the researcher.

IHC staining of FFPE human spleen tissue with S100A12 antibody. HIER: boil tissue sections in pH8 EDTA for 20 min and allow to cool before testing.