S100B Antilichaam (9A11B9]

S100B (S100 calcium binding protein B) is a member of the S100 family of proteins containing 2 EF-hand calcium binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S-100 proteins and parvalbumin proteins are each expressed in neural tissues. In addition, S100B are present in a variety of other tissues, and calbindin is present in intestine and kidney. Parvalbumin B is found in many tumor tissues as well as in the organ of Corti. Calbindin, S-100 proteins and parvalbulmins have all been detected in leydig cells and the testis. These proteins are thought to play a role in hormone production and spermatogenesis. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.

6285

P04271

P04271

Human

Purified full-length recombinant S100B-GST expressed in E. Coli strain BL21 (DE3) .

9A11B9

Unconjugated

Primary Antibodies

Neuroscience

Batch dependent

Ascitic fluid containing 0.03% sodium azide.

None

Blue Ice

S100B monoclonal antibody can be stored at -20˚ C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG1

S100B

S100 calcium binding protein B

Homo sapiens

Shapiro LA. Marks A. Whitaker-Azmitia PM. Brain Res. 2004, Jun 4,1010 (1-2) :17-21.

Sorci G. Riuzzi F. Arcuri C. et al. Mol Cell Biol. 2004, Jun,24 (11) :4880-94.

Zimmer DB. Chaplin J. Baldwin A. et al. Cell Mol Biol (Noisy-le-grand) .2005, Sep 5,51 (2) :201-14.

S-100 protein beta chainNEF, S100, S100-B, S100beta

ELISA, WB, IHC

134138