S1PR2 Antilichaam

The Sphingosine 1-phosphate receptor 2 (S1PR2) protein was initially identified as G-protein coupled receptor thought to be involved in development (1) and was found to mediate sphingosine 1-phosphate (SPP) -induced cell rounding and neurite retraction (2) . S1PR2 and the related protein S1PR3 (also known as EDG3) are also thought to mediate the SPP-induced cell proliferation, survival, and related signaling events (3) . S1PR2 has also been found to be key regulator in acute vascular inflammation and may be a novel therapeutic target for vascular disorders (4) .

9294

O95136

NP_004221

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Stem Cell, Signal Transduction, Immunology

S1PR2 antibody is affinity chromatography purified via peptide column.

Cat. No. 1201 - HeLa Cell Lysate

1 mg/mL

S1PR2 antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

S1PR2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

Multiple transmembrane protein, also multiple other S1PR2 antibodies also show a ~50kD band

IgG

S1PR2 antibody is human, mouse and rat reactive.

S1PR2

Sphingosine-1-phosphate receptor 2

Homo sapiens

MacLennan AJ, Browe CS, Gaskin AA, et al. Cloning and characterization of a putative G-protein coupled receptor potentially involved in development. Mol. Cell Neurosci. 1994; 5:201-9.

Van Brocklyn JR, Tu Z, Edsall LC, et al. Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218. J. Biol. Chem. 1999; 274:4626-32.

An S, Zheng Y, and Bleu T. Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5. J. Biol. Chem. 275:288-96.

Zhang G, Yang L, Kim GS, et al. Critical role of sphingosine-1-phosphate receptor 2 (S1PR2) in acute vascular inflammation. Blood 2013; 122:443-55.

Sphingosine 1-phosphate receptor 2, S1P2, AGR16, EDG-5, EDG5, Gpcr13, H218, LPB2

ELISA, WB, IHC-P, IF

134244587

Liquid