S9-CMC1 (TFA)

S9-CMC1 TFA is a covalent peptide lysine-specific demethylase 1 (LSD1) inhibitor with an IC50 value of 2.53 μM. S9-CMC1 TFA specifically recognizes Cys360 in the enzyme-active region. S9-CMC1 TFA inhibits LSD1 activity, increasing H3K4me1 and H3K4me2 levels, leading to G1 cell cycle arrest and apoptosis and inhibiting cell proliferation. S9-CMC1 TFA significantly inhibits tumor growth in A549 xenograft animal models[1].

12352209

Apoptosis; Histone Demethylase

Apoptosis; Epigenetics

Cancer-programmed cell death

Cancer

O=C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CSCC1=CC=CC2=C1)C(N[C@@H](CC3=CC=CC=C3)C(N[C@@H](CC(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CC[S+](C2)C)C(N[C@@H](CCCCN)C(N4[C@@H](CCC4)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC5=CNC6=CC=CC=C56)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H]7N(C(C)=O)CCC7.[O-]C(C(F)(F)F)=O

C97H151F3N32O17S2

2158.57

[1]Luo Q, et al. Covalent Peptide LSD1 Inhibitor Specifically Recognizes Cys360 in the Enzyme-Active Region. J Med Chem. 2023 Nov 23;66 (22) :15409-15423.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-P10819/

Peptides

No Development Reported