Sacubitrilat-13C4
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Sacubitrilat-13C4 (Desethyl Sacubitril-13C4) is 13C labeled Sacubitrilat. Sacubitrilat (Desethyl Sacubitril) is an active neprilysin (NEP) inhibitor.
Desethyl Sacubitril-13C4; LBQ-657-13C4
12352005
Isotope-Labeled Compounds; Neprilysin
Metabolic Enzyme/Protease; Others
Neuroscience-Neuromodulation
Neurological Disease
[H]N([C@@H](C[C@@H](C)C(O)=O)CC1=CC=C(C2=CC=CC=C2)C=C1)[13C]([13CH2][13CH2][13C](O)=O)=O
C18 13C4H25NO5
387.41
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Schiering N, et al. Structure of neprilysin in complex with the active metabolite of sacubitril. Sci Rep. 2016 Jun 15;6:27909.|[3]Langenickel TH, et al. Single therapeutic and supratherapeutic doses of sacubitril/valsartan (LCZ696) do not affect cardiac repolarization. Eur J Clin Pharmacol. 2016 Aug;72 (8) :917-24.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-W747097/
Isotope-Labeled Compounds
No Development Reported
Beschrijving
Sacubitrilat-13C4 (Desethyl Sacubitril-13C4) is 13C labeled Sacubitrilat. Sacubitrilat (Desethyl Sacubitril) is an active neprilysin (NEP) inhibitor.
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