SAFB-antilichaam

This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA) . This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript variants encoding different isoforms have been found for this gene.

6294

Q15424

Human, Mouse, Rat

A synthetic peptide corresponding to a sequence within amino acids 300-400 of human SAFB (NP_002958.2) .

Unconjugated

Primary Antibodies

Other

Affinity purification

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

IgG

SAFB

Scaffold attachment factor B

Homo sapiens

SAFB, HAP, HET, Scaffold attachment factor B, SAB-B1, SAFB1, SAF-B, SAF-B1, Scaffold attachment factor B1, Hsp27 ERE-TATA binding protein, HSP27 ERE-TATA-binding protein

WB, IF

Liquid