Salicylaat (choline)

Salicylate choline is an orally active derivative of Aspirin (acetylsalicylic acid). Salicylate choline significantly reduces IL-1β, IL-6, TNF-α and IL-10 levels in cells. Salicylate choline enhances the anti-tumor activity of the CRM1 inhibitor Selinexor (KPT-330) (HY-17536) through inducing S-phase cell cycle arrest and impairing DNA damage repair. Salicylate choline combined with Selinexor demonstrates excellent anti-tumor efficacy in mice xenograft model harboring JeKo-1 cells. Salicylate choline can be used for the study of rheumatic diseases, inflammation and cancer[1][2][3][4].

2016-36-6

12352005

H302-H315-H319-H335

Drug Derivative; Interleukin Related; Polo-like Kinase (PLK) ; TNF Receptor

Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Others

Cancer; Inflammation/Immunology

O=C(O)C1=CC=CC=C1[O-].C[N+](C)(CCO)C

C12H19NO4

241.28

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

[1]Wróblewska KB, et al. Choline Salicylate Analysis: Chemical Stability and Degradation Product Identification. Molecules. 2019 Dec 22;25 (1) :51. |[2]SCULLY FJ. Choline salicylate: an effective, well-tolerated drug for treatment of rheumatic diseases. South Med J. 1960 Jan;53:12-6. |[3]Tiras M, et al. In vitro assessment of cytokine modulation by choline salicylate, hyaluronic acid, lidocaine-based six different teething gels in human gingival fibroblast cells. Odontology. 2025 May 13. |[4]Abeykoon JP, et al. Salicylates enhance CRM1 inhibitor antitumor activity by induction of S-phase arrest and impairment of DNA-damage repair. Blood. 2021 Jan 28;137 (4) :513-523.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W338346/

Reference compound2

No Development Reported