SAP18 Antibody - N-terminal regio : HRP (ARP38690_P050-HRP)

Sin3A-associated protein, 18kDa

SAP18P, 2HOR0202

10284

O00422

NP_005861

Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish

The immunogen is a synthetic peptide directed towards the N terminal region of human SAP18

Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. SAP18 is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter.Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter.

INCA1; RBM39; UBC; RNF2; SUZ12; BMI1; CSNK2A2; MAGOH; EIF4A3; VCP; NFIA; SEPT2; MYO1C; IK; HNRNPU; HNRNPC; GTF3C1; SEPT7; CDC5L; U2AF1; SNRPD2; SMARCC2; SMARCB1; SRSF7; SRSF5; SRSF3; SRSF1; SAFB; S100A9; PSAP; NHP2L1; TPR; TFPI; SURF4; SSRP1; SSR3; LOC255

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB, IHC

Affinity Purified

0.5 mg/ml

Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 93%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

18kDa

Zhang, Y., (1997) Cell 89 (3), 357-364

Wet Ice

153

SAP18

SAP18

Rabbit

Histone deacetylase complex subunit SAP18

NM_005870

EIKKEPEKPIDREKTCPLLLRVFTTNNGRHHRMDEFSRGNVPSSELQIYT

SAP18