SAR-439459
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
SAR-439459 is a human monoclonal antibody (mAb) targeting TGFB1/TGFβ-1. SAR-439459 blocks TGFβ-mediated pSMAD signaling, and suppression of T cells and NK cells. SAR-439459 has anti-tumor activity [1].
12352203
TGF-β Receptor
TGF-beta/Smad
Cancer-Kinase/protease
Cancer
[SAR-439459]
[1]Greco R, et al. Pan-TGFβ inhibition by SAR439459 relieves immunosuppression and improves antitumor efficacy of PD-1 blockade. Oncoimmunology. 2020 Sep 13;9 (1) :1811605.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-P991382/
Inhibitory Antibodies
No Development Reported
Beschrijving
SAR-439459 is a human monoclonal antibody (mAb) targeting TGFB1/TGFβ-1. SAR-439459 blocks TGFβ-mediated pSMAD signaling, and suppression of T cells and NK cells
Specificaties
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