Sarcosine-13C3

Sarcosine-13C3 (N-Methylglycine-13C3; Sarcosin-13C3) is the 13C-labeled Sarcosine. Sarcosine (N-Methylglycine), an endogenous amino acid, is a competitive glycine transporter type I (GlyT1) inhibitor and N-methyl-D-aspartate (NMDA) receptor co-agonist. Sarcosine increases the glycine concentration, resulting in an indirect potentiation of the NMDA receptor. Sarcosine is commonly used for the research of schizophrenia[1][2].

2806125-84-6

N-Methylglycine-13C3; Sarcosin-13C3

12352211

Endogenous Metabolite; GlyT; Isotope-Labeled Compounds

Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; Others

Cancer

O[13C]([13C]([H])(N[13CH3])[H])=O

13C3H7NO2

92.07

[1]Katarzyna Socała, et al. Effects of sarcosine, a glycine transporter type 1 inhibitor, in two mouse seizure models. Pharmacol Rep. Mar-Apr 2010;62 (2) :392-7.|[2]Mei-Yi Lee, et al. Effects of sarcosine and N, N-dimethylglycine on NMDA receptor-mediated excitatory field potentials. J Biomed Sci. 2017; 24: 18.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-W748519/

Isotope-Labeled Compounds

No Development Reported