SARS-CoV-2 (COVID-19) 3CL-PRO (NSP5) Antilichaam

Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1) . The disease is the cause of the 2019–20 coronavirus outbreak (2) . The structure of 2019-nCoV consists of the following: a spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. 3C- like proteinase (NSP5) cleaves the C-terminus of replicase polyprotein at 11 sites (3,4,5) . It recognizes substrates containing the core sequence [ILMVF]-Q-|-[SGACN]. It also able to bind an ADP-ribose-1''-phosphate (ADRP) (5) .

43740578

P0DTC1

YP_009742612.1

Virus

9153

Unconjugated

Primary Antibodies

Infectious Disease, COVID-19

SARS-CoV-2 (COVID-19) 3CL-PRO (NSP5) Antibody is affinity chromatography purified via peptide column.

1 mg/mL

Predicted reactivity based on immunogen sequence: SARS-CoV 3CL-PRO (NSP5) protein: (100%)

SARS-CoV-2 (COVID-19) 3CL-PRO (NSP5) Antibody is supplied in PBS containing 0.02% sodium azide.

Blue Ice

SARS-CoV-2 (COVID-19) 3CL-PRO (NSP5) antibody can be stored at 4 ˚ C for three months and -20 ˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

3CL-PRO

ORF1a polyprotein; ORF1ab polyprotein

Severe acute respiratory syndrome coronavirus 2

Gorbalenya. bioRxiv: 2020.

Hui et al. Int J Infect Dis. 2020;91:264-266.

Zhang et al. Science. 2020; 0:0-0 (2020)

Jin et al. Nature, 0:0-0 (2020)

Dai et al. Science 0:0-0 (2020)

3C-like proteinase, 3CLp, nsp5, Non-structure protein 5, Main protease, Mpro

ELISA, WB, IHC

1826688922

Liquid