SARS-CoV-2 (COVID-19) ORF3a Antilichaam

Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1) . The disease is the cause of the 2019–20 coronavirus outbreak (2) . SARS-CoV-2 virus proteins include structural proteins, non-structural proteins and accessory factors. The structure of SARS-CoV-2 consists of the following: a spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. SARS-CoV-2 non-structural protein is ORF1ab that consists of 16 proteins (nsp1-nsp16), while accessory factors include ORF3a, ORF3b, ORF6, ORF7a, ORF7b, ORF8, ORF9b, ORF9c and ORF10. ORF3a forms homotetrameric potassium sensitive ion channels (viroporin) and may modulate virus release. It up-regulates expression of fibrinogen subunits FGA, FGB and FGG in host lung epithelial cells. It induces apoptosis in cell culture and downregulates the type 1 interferon receptor by inducing serine phosphorylation within the IFN alpha-receptor subunit 1 (IFNAR1) degradation motif and increasing IFNAR1 ubiquitination (3) .

43740569

P0DTC3

P0DTC3

Virus

9275

Unconjugated

Primary Antibodies

Infectious Disease, COVID-19

SARS-CoV-2 (COVID-19) ORF3a Antibody is affinity chromatography purified via peptide column.

1 mg/mL

SARS-CoV-2 (COVID-19) ORF3a antibody is supplied in PBS containing 0.02% sodium azide.

Blue Ice

SARS-CoV-2 (COVID-19) ORF3a antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

ORF3a

ORF3a protein

Severe acute respiratory syndrome coronavirus 2

Gorbalenya. bioRxiv: 2020.

Hui et al. Int J Infect Dis. 2020;91:264-266.

Lu et al. PNAS USA. 2006; 103:12540-12545.

ORF3a protein, Accessory protein 3a, Protein 3a, Protein U274, Protein X1, ORF3a

ELISA, IHC

1835921851

Liquid