SARS-CoV-2 Spike P26S Antilichaam (Gamma Variant)

In January of 2021 a new lineage of SARS-CoV-2, known as P.1 and named as Gamma variant, was discovered in Japan and later spread in Brazil. It is considered as VOC (variant of concern) . This variant carries 10 mutations in spike protein, including N501Y, E484K and K417T in RBD, which can increase the affinity to the human ACE2 receptor. Enhanced transmission of the Gamma variant (P.1 lineage) was observed globally, which is 3.5 times more contagious as the original one. The Gamma variant affects the effectiveness of COVID19 vaccine and is resistant to neutralization to some extent due to the immune escape E484K mutation.

43740568

P0DTC2

QHD43416

Virus

9573

Unconjugated

Primary Antibodies

Infectious Disease, COVID-19

SARS-CoV-2 Spike P26S (Gamma Variant) antibody is affinity chromatography purified via peptide column.

1 mg/mL

Predicted reactivity based on immunogen sequence: SARS-CoV Spike proteins: (36.4%)

SARS-CoV-2 Spike P26S antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

SARS-CoV-2 Spike P26S antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

It can only detect SARS-CoV-2 Gamma Variant (P.1) Spike S1 protein and does not cross-react with the spike protein of other variants.

S

Surface glycoprotein

Severe acute respiratory syndrome coronavirus 2

Voloch et al. Journal of Virology 2021, 95 (10) : e00119-21.

Wang et al. Cell Host & Microbe 2021, 29 (5) : 747-751.

Wang et al. Nature 592, 616-622.

SARS-CoV-2 (COVID-19) Spike Antibody: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Surface Glycoprotein, Spike protein

ELISA, WB

1791269090

Liquid