SARS-CoV-2 Spike Trimer Proteïne, zijn tag (XEC)

XEC is a recombinant SARS‑CoV‑2 Omicron subvariant formed from KP.3.3 and KS.1.1 lineages. First detected in samples from Italy in May 2024 and identified in Berlin that August1, it has since spread globally, with notable growth in Europe and the Americas. Early data suggest slightly higher transmissibility than KP.3.1.1, but current vaccines targeting JN.1/KP.2 remain effective3

SARS-CoV-2 Spike Trimer Protein, His Tag (XEC) (SPN-S522c) is expressed from human 293 cells (HEK293) . It contains AA Val 16 - Pro 1213 (Accession # QHD43416.1 (T19I, R21T, T22N, A27S, S50L, F59S, V127F, G142D, F157S, R158G, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, E484K, F486P, Q493E, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, F817P, A892P, A899P, A942P, K986P, V987P, D796Y, S939F, Q954F, N969K, P1143L) ) . The recombinant protein is expressed from human 293 cells (HEK293) with T4 fibritin trimerization motif and a polyhistidine tag at the C-terminus. Proline substitutions (F817P, A892P, A899P, A942P, K986P, V987P) are introduced to stabilize the trimeric prefusion state of SARS-CoV-2 S protein.

This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 138.6 kDa. The protein migrates as 80-90 kDa and 100-110 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) .

Val 16 - Pro 1213

Spike protein

Unconjugated

C-10xHis

-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.

1.0 EU per μg

90%

Powder

0.1 M Sodium citrate

138.6 kDa

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RT

-20°C

100ug*1

HEK293

SARS-CoV-2

QHD43416.1 (T19I, R21T, T22N, A27S, S50L, F59S, V127F, G142D, F157S, R158G, L212I, V213G, L216F, H245N, A264D, I332V, G339H, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, V445H, G446S, N450D, L452W, L455S, F456L, N460K, S477N, T478K, N481K, E484K, F486P, Q493E, Q498R, N501Y, Y505H, E554K, A570V, D614G, P621S, H655Y, N679K, P681R, N764K, F817P, A892P, A899P, A942P, K986P, V987P, D796Y, S939F, Q954F, N969K, P1143L)

Trehalose