SARS-CoV Envelop Antilichaam

SARS Envelope Antibody: A novel coronavirus has recently been identified as the causative agent of SARS (Severe Acute Respiratory Syndrome) . Coronaviruses are a major cause of upper respiratory diseases in humans. The genomes of these viruses are positive-stranded RNA approximately 27-31kb in length. SARS infection can be mediated by the binding of the viral spike protein, a glycosylated 139 kDa protein and the major surface antigen of the virus, to the angiotensin-converting enzyme 2 (ACE2) on target cells. This binding can be blocked by a soluble form of ACE2. Envelope protein is a small polypeptide that contains at least one α-helical transmembrane domain. It involves in several aspects of the virus's life cycle, such as assembly, budding, envelope formation, and pathogenesis. E protein has membrane permeabilizing activity, which provides a possible rationale to inhibit in vitro ion channel activity of some synthetic coronavirus E proteins, and also viral replication.

1489671

P59637

P59637

Virus

3533

Unconjugated

Primary Antibodies

Neuroscience, Infectious Disease, COVID-19

SARS-CoV Envelope Antibody is affinity chromatography purified via peptide column.

1 mg/mL

Predicted reactivity based on immunogen sequence: SARS-CoV-2 Envelope protein: (identity 82%, homology 91%)

SARS-CoV Envelope Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

SARS-CoV Envelope antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

SARS-CoV Envelope antibody can be used for the detection of SARS-CoV Envelope protein in ELISA. It will detect 5 ng of free peptide at 1 μ g/mL.

SARS-CoV Envelope has one isoform (75aa) .

E

Envelope small membrane protein

SARS coronavirus

Marra et al. Science 2003;300:1399-404.

Rota et al. Science 2003;300:1394-9.

Navas-Nartin et al. J Neurovirol. 2004;10:75-85.

Pervushin et al. PLoS Pathog. 2009; 5 (7) : e1000511.

18753196

SARS-CoV Envelope Antibody: sM, 4, Envelope small membrane protein, E protein

ELISA

30173401

Liquid