SARS-CoV Matrix Antilichaam

Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus (1) . The disease is the cause of the 2019–20 coronavirus outbreak (2) . The structure of 2019-nCoV consists of the following: a spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. The membrane (M) protein or matrix protein is the most abundant structural protein and defines the shape of the viral envelope (3) . It is an integral membrane protein involved in the budding of the viral particles and interacts with S (Spike) protein. It involves in organization of the nucleoprotein inside, which includes many copies of the N (nucleocapsid) protein bound to the genomic RNA. The M protein holds dominant cellular immunogenicity and has been determined as a protective antigen in humoral responses, which suggests it would serve as a potential target in vaccine design (4) .

1489672

P59596

P59596

Virus

3527

Unconjugated

Primary Antibodies

Infectious Disease, COVID-19

SARS-CoV Matrix Antibody is affinity chromatography purified via peptide column.

1 mg/mL

Predicted reactivity based on immunogen sequence: SARS-CoV-2 Matrix protein: (identity 77%, homology 93%)

SARS-CoV Matrix Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

SARS-CoV Matrix antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

SARS-CoV Matrix antibody can be used for the detection of SARS-CoV Matrix protein in ELISA. It will detect 5 ng of free peptide at 1 μ g/mL.

SARS-CoV Matrix has one isoform (222aa) .

M

Membrane protein

SARS coronavirus

Gorbalenya. bioRxiv: 2020.

Hui et al. Int J Infect Dis. 2020;91:264-266.

Neuman, et al. J Struct Biol. 2011;174 (1) :11–22.

Liu et al. J Infect Dis. 2010;202 (8) :1171-80.

21775467

32743576

SARS-CoV Matrix Antibody: Membrane protein, E1 glycoprotein, M protein

ELISA

30173398

Liquid