SB-408124 (Standaard)

SB-408124 (Standard) is the analytical standard of SB-408124. This product is intended for research and analytical applications. SB-408124 is a non-peptide OX1 receptor antagonist with Kis of 57 nM and 27 nM in whole cell and membrane, respectively. SB-408124 exhibits 50-fold selectivity over OX2 receptor[1].

288150-92-5

12352100

Orexin Receptor (OX Receptor) ; Reference Standards

GPCR/G Protein; Neuronal Signaling; Others

Neurological Disease; Endocrinology

O=C(NC1=CC(C)=NC2=C(C=C(C=C21)F)F)NC3=CC=C(C=C3)N(C)C

C19H18F2N4O

356.37

[1]Langmead CJ, et al. Characterisation of the binding of [3H]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor. Br J Pharmacol. 2004;141 (2) :340-346.|[2]Kis GK, et al. The osmotically and histamine-induced enhancement of the plasma vasopressin level is diminished by intracerebroventricularly administered orexin in rats. Pflugers Arch. 2012;463 (4) :531-536.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-70068R/

Reference Standards