SB-525334
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Potent and selective inhibitor of the transforming growth factor beta 1 receptor, activin receptor-like kinase (ALK5), IC50 = 14.3 nM and ALK4 (IC50 = 58.5 nM) with no activity at ALK2, 3 and 61. Blocks fibrosis markers and renal injury in the puromycin-induced nephritis model1. It causes significant attenuation in Smad2/3 nuclear translocation, decrease in CTGF-expressing cells, myofibroblast proliferation and type 1 collagen deposition resulting in an overall attenuation in bleomycin-induced pulmonary fibrosis2. Sensitizes drug-resistant pancreatic cancer cells to gemcitabine3. Cell permeable and active in vivo.
Unconjugated
Yellow solid
-20°C
Beschrijving
SB-525334 Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
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