SC-560 (Standaard)

SC-560 (Standard) is the analytical standard of SC-560. This product is intended for research and analytical applications. SC-560 is a potent and selective COX-1 inhibitor with an IC50 of 9 nM.

188817-13-2

12352100

COX; Reference Standards

Immunology/Inflammation; Others

Cancer

FC(C1=NN(C2=CC=C(OC)C=C2)C(C3=CC=C(Cl)C=C3)=C1)(F)F

C17H12ClF3N2O

352.74

[1]Smith CJ, et al. Pharmacological analysis of cyclooxygenase-1 in inflammation. Proc Natl Acad Sci U S A. 1998 Oct 27;95 (22) :13313-8.|[2]Lampiasi N, et al. The selective cyclooxygenase-1 inhibitor SC-560 suppresses cell proliferation and induces apoptosis in human hepatocellular carcinoma cells. Int J Mol Med. 2006 Feb;17 (2) :245-52.|[3]Teng XW, et al. Formulation dependent pharmacokinetics, bioavailability and renal toxicity of a selective cyclooxygenase-1 inhibitor SC-560 in the rat. J Pharm Pharm Sci. 2003 May-Aug;6 (2) :205-10.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-59105R/

Reference Standards