SC-58125 (Standaard)
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
SC-58125 is a potent and selective inhibitor of cyclooxygenase 2 (COX-2), with an IC50 of 0.04 μM. SC-58125 exhibits antitumor activity in vitro and in vivo. SC-58125 also can inhibit edema at the inflammatory site and has analgesic effect[1][2][3].
162054-19-5
12352005
COX
Immunology/Inflammation
Cancer; Inflammation/Immunology
FC(C1=NN(C2=CC=C(S(=O)(C)=O)C=C2)C(C3=CC=C(F)C=C3)=C1)(F)F
C17H12F4N2O2S
384.35
[1]Gierse JK, et, al. A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors. J Biol Chem. 1996 Jun 28; 271 (26) : 15810-4.|[2]Seibert K, et, al. Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc Natl Acad Sci U S A. 1994 Dec 6; 91 (25) : 12013-7.|[3]Williams CS, et, al. A cyclooxygenase-2 inhibitor (SC-58125) blocks growth of established human colon cancer xenografts. Neoplasia. Sep-Oct 2001; 3 (5) : 428-36.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-W013164R/
Reference Standards
Beschrijving
SC-58125 is a potent and selective inhibitor of cyclooxygenase 2 (COX-2), with an IC50 of 0.04 μM. SC-58125 exhibits antitumor activity in vitro and in vivo. SC
Specificaties
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