SCD27 Ligand Recombinant Proteïne

CD27 Ligand, a type II transmembrane protein, is a member of the TNF superfamily. It is expressed on activated T and B lymphocytes as well as NK cells. CD27L and its receptor (CD27) regulate the immune response by promoting T-cell expansion and differentiation, as well as NK enhancement. CD27 signaling can act as a co-stimulatory effector to sustain the survival of CD8+ T cells, primarily by inducing increased expression of the IL-2 gene. Full length human CD27L is a 193 amino acid protein, consisting of a 17 amino acid cytoplasmic domain, a 21 amino acid transmembrane domain, and a 155 amino acid extracellular domain. Human soluble CD27L corresponds to the 155 amino acid extracellular domain of the full length CD27L protein. ProSci’s recombinant human sCD27L contains the extracellular domain plus an N-terminal His-Tag.

970

P32970

NP_001243.1

Recombinant Proteins

CHO cells

Cancer, Immunology, Signal Transduction, Other

Greater than 95% by SDS-PAGE gel and HPLC analyses.

Room Temp

The lyophilized sCD27 Ligand recombinant protein is stable for at least 2 years from date of receipt at -20˚ C. Reconstituted sCD27 Ligand stable for at least 3 months when stored in working aliquots with a carrier protein at -20˚ C. As with any protein, exposing sCD27 Ligand recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.

CD70 molecule

Homo sapiens

CD27L, CD27LG, TNFSF7, CD27L, CD70 antigen, CD27 ligand, CD27-L

Human

4507605

Lyophilized