SCF Antilichaam

Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol-1, 4, 5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.

4254

P21583

NP_000890.1

Human

SCF antibody was raised against a peptide sequence around aa.265~269 (E-K-E-R-E) derived from Human SCF.

Unconjugated

Primary Antibodies

Stem Cell

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

1 mg/mL

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

None

Blue Ice

Store antibody at -20˚ C for up to one year.

25 - 38 kDa

This antibody detects endogenous level of total SCF protein.

Western Blot: 1:500~1:1000

KITLG

KIT ligand

Homo sapiens

Lu H. S., Clogston C. L., Wypych J., Parker V. P., Lee T. D., Swiderek K., Baltera R. F. Jr., Patel A. C., Chang D. C., Brankow D. W., Liu X. -D., Ogden S. G., Karkare S. B., Hu S. S., Zsebo K. M., Langley K. E. Arch. Biochem. Biophys. 298:150-158 (1992)

SF, MGF, SCF, FPH2, KL-1, Kitl, SHEP7, BCR1, D22S11, SF

WB

4505175

Liquid