SCH-23390

SCH-23390 is a dopamine D1-like receptor antagonist (with Ki values of 0.2 nM and 0.3 nM for the D1 and D5 receptor subtypes, respectively). SCH-23390 can shorten the latency period for cocaine-induced lever pressing behavior in rats. SCH-23390 can also eliminate generalized seizures caused by chemical convulsants, such as arecoline and strychnine, and is used in research on neurological disorders related to the dopamine system[1][2].

87075-17-0

R- (+) -SCH-23390

12352005

Dopamine Receptor

GPCR/G Protein; Neuronal Signaling

Neurological Disease

OC1=C(Cl)C=C2CCN(C)C[C@H](C3=CC=CC=C3)C2=C1

C17H18ClNO

287.78

[1]Dakota B Zinani, et al. SCH23390 and a humanized anti-cocaine mAb decrease the latency to cocaine-induced reinstatement of lever pressing behavior in rats that self-administer cocaine. Sci Rep. 2023 Sep 4;13 (1) :14566.|[2]J A Bourne, et al. SCH 23390: the first selective dopamine D1-like receptor antagonist.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-19545/

Reference compound1

No Development Reported

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