SCH-602539
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
SCH-602539 is a selective PAR-1 antagonist. SCH-602539 inhibits platelet aggregation in response to PAR-1-selective high-affinity thrombin receptor agonist peptide. SCH-602539 exhibits synergistic antithrombotic effects when used in combination with Cangrelor.
618385-42-5
12352005
Protease Activated Receptor (PAR)
GPCR/G Protein
Cardiovascular Disease
O=C(OCC)N[C@H]1C[C@@]2([H])C[C@]3([H])[C@@]([C@@H](/C=C/C4=CC=C(C5=NC=CC=C5)C=N4)[C@]2([H])CC1)([H])[C@@H](C)OC3=O
C28H33N3O4
475.58
[1]Chintala M, et al. SCH 602539, a protease-activated receptor-1 antagonist, inhibits thrombosis alone and in combination with cangrelor in a Folts model of arterial thrombosis in cynomolgus monkeys. Arterioscler Thromb Vasc Biol. 2010 Nov;30 (11) :2143-9.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-18201/
Reference compound1
No Development Reported
PAR1
Beschrijving
SCH-602539 is a selective PAR-1 antagonist. SCH-602539 inhibits platelet aggregation in response to PAR-1-selective high-affinity thrombin receptor agonist pept
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