SCN7A Antilichaam

This gene encodes one of the many voltage-gated sodium channel proteins. For proper functioning of neurons and muscles during action potentials, voltage-gated sodium channels direct sodium ion diffusion for membrane depolarization. This sodium channel protein has some atypical characteristics; the similarity between the human and mouse proteins is lower compared to other orthologous sodium channel pairs. Also, the S4 segments, which sense voltage changes, have fewer positive charged residues that in other sodium channels; domain 4 has fewer arginine and lysine residues compared to other sodium channel proteins. Several alternatively spliced transcript variants exist, but the full-length natures of all of them remain unknown.

6332

Q01118

Human, Mouse

Recombinant fusion protein containing a sequence corresponding to amino acids 265-368 of human SCN7A (NP_002967.2) .

Unconjugated

Primary Antibodies

Neuroscience

Affinity purification

HeLa

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 260kDa

IgG

WB: 1:500 - 1:2000

SCN7A

HT-1080

Mouse heart

Sodium voltage-gated channel alpha subunit 7

Homo sapiens

NaG, Nav2.1, Nav2.2, SCN6A, sodium channel protein type 7 subunit alpha, putative voltage-gated sodium channel subunit alpha Nax, sodium channel protein cardiac and skeletal muscle subunit alpha, sodium channel protein type VII subunit alpha, sodium channel, voltage-gated, type VI, alpha polypeptide, sodium channel, voltage-gated, type VII, alpha subunit, voltage-dependent sodium channel alpha subunit

WB

Liquid