SCO2 Antilichaam

SCO2 Antibody: Synthesis of cytochrome c oxidase 2 was initially identified in yeast as one of two cytochrome c oxidase (COX) assembly proteins that enable the assembly of cytochrome c holoenzyme, a complex that catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. Like their yeast homologs, the function of both SCO2 and SCO1 are dependent on copper ion binding. Recent studies suggest that SCO2 expression is regulated by p53, so that a decrease in p53 expression, such as in numerous tumors and cells lines, the drop in SCO2 expression leads to a shift from normal aerobic respiration towards the production of glycolytic ATP. Defects in the SCO2 protein are also associated with fatal infantile cardioencephalomyopathy and COX deficiency.

9997

O43819

O43819

Human

Unconjugated

Primary Antibodies

Homeostasis

SCO2 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1209 - HL60 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Mouse: (84%), Bovine: (84%)

SCO2 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

SCO2 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

SCO2

Cat. No. 10-201 - Human Liver Tissue Slide

Cytochrome c oxidase assembly protein

Homo sapiens

Glerum DM, Shtanko A, and Tzagoloff A. SCO1 and SCO2 act as high copy suppressors of a mitochondrial copper recruitment defect in Saccharomyces cerevisiae. J. Biol. Chem. 1996; 271:20531-5.

Horng Y-C, Leary SC, Cobine PA, et al. Human Sco1 and Sco2 function as copper-binding proteins. J. Biol. Chem. 2005; 280:34113-22.

Matoba S, Kang J-G, Patino WD, et al. p53 regulates mitochondrial respiration. Science 2006; 312:1650-3.

Papadopoulou LC, Sue CM, Davidson MM, et al. Fatal infantile cardioencephalomyopathy with COX deficiency and mutations in SCO2, a COX assembly gene. Nat. Genetics 1999; 23:333-7.

SCO2 Antibody: SCOD1, Protein SCO2 homolog, mitochondrial

ELISA, WB, IHC-P, IF

8134662

Liquid