SCUBE1 Antilichaam

SCUBE1 Antibody: SCUBE1 is an EGF-related protein with a CUB (C1s-like) domain that is expressed primarily in the developing gonad, nervous system, somites, surface ectoderm and limb buds. The N-terminal EGF-like repeats of SCUBE1 participate in the formation of adhesions in a Ca2+-dependent fashion. In contrast, the C-terminal cysteine-rich motifs and CUB domain can directly bind and antagonize bone morphogenic protein activity; genetic ablation of this region resulted in brain malformation in mice embryos, suggesting SCUBE1 plays a role in brain morphogenesis. SCUBE1 has also been implicated in early craniofacial development in mice.

80274

Q8IWY4

NP_766638

Human

Unconjugated

Primary Antibodies

Stem Cell

SCUBE1 Antibody is affinity chromatography purified via peptide column.

Cat. No. 1224 - Daudi Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Mouse: (93%)

SCUBE1 Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

SCUBE1 antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

SCUBE1

Signal peptide, CUB domain, EGF-like 1

Homo sapiens

Grimmond S, Larder R, Van Hateren N, et al. Cloning, mapping, and expression analysis of a gene encoding a novel mammalian EGF-related protein (SCUBE1) . Genomics2000; 70:74-81.

Tu C, Yan Y, Wu S, et al. Domain and function analysis of a novel platelet-endothelial cell surface protein, SCUBE1. J. Biol. Chem.2008; 283:12478-88.

Xaiver GM, Sharpe PT, and Colbourne MT. Scube1 is expressed during facial development in the mouse. J. Exp. Zool. B. Mol. Dev. Evol.2009; 312B:518-24.

SCUBE1 Antibody: Signal peptide, CUB and EGF-like domain-containing protein 1

ELISA, WB, ICC, IF

120587029

Liquid