SDF-1 alfa (CXCL12)

Stromal cell-derived factor (SDF) -1 alpha and SDF-1 beta are the first cytokines initially identified using the signal sequence trap cloning strategy from a mouse bone-marrow stromal cell line. They are encoded by a single gene, PBSF, and arise by alternative splicing. The two proteins are identical except for the four amino acid residues that are present in the carboxy-terminus of SDF-1 beta and absent from SDF-1 alpha. SDF-1/PBSF is highly conserved between species. Human mature SDF-1 shares approximately 99% amino acid sequence identity with the mouse protein.

Cxcl12; Sdf1

24772

Q9QZD1

NP_071513.1

NM_022177.3

4q42.1

Rat

Human

KPVSLSYRCP CRFFESHVAR ANVKHLKILN TPNCALQIVA RLKSNNRQVC IDPKLKWIQE YLDKALNK

< 0.1 ng/µg of protein (< 1EU/µg)

> 98% by SDS-PAGE & HPLC analyses

Determined by its ability to chemoattract human peripheral blood monocytes using a concentration range of 50.0-100.0 ng/ml.

68

Lyophilized

7.9 kDa

E. coli