SDHB-antilichaam

Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.

6390

P21912

Human, Mouse, Rat

Recombinant fusion protein containing a sequence corresponding to amino acids 29-280 of human SDHB (NP_002991.2) .

Unconjugated

Primary Antibodies

Cancer, Cell Cycle, Neuroscience, Signal Transduction

Affinity purification

HepG2

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 32kDa

IgG

SDHB

HeLa

U-87MG

Mouse brain

Mouse liver

Mouse kidney

Succinate dehydrogenase complex, subunit B, iron sulfur (Ip)

Homo sapiens

SDHB, IP, PGL4, SDH, SDH1, SDHIP, CWS2, SDH2

WB, IHC

Liquid