SDHB-antilichaam - middengebied: FITC (ARP47981_P050-FITC)

Succinate dehydrogenase complex, subunit B, iron sulfur (Ip)

IP, SDH, CWS2, PGL4, SDH1, SDH2, SDHIP, MC2DN4

6390

P21912

NP_002991

Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish

The immunogen is a synthetic peptide directed towards the middle region of human SDHB

Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

UBC; XRN1; ITGA4; TP53BP1; HNRNPUL2; PIGS; TIMM50; MRPL45; SLC25A22; MRPL40; MRPS5; IWS1; MRPS10; MRPL20; OCIAD1; TOMM7; NDUFB11; LAMTOR2; TMED2; TOMM40; RBM14; IQGAP1; UQCRFS1; SSBP1; SDHA; OXA1L; NDUFV2; NDUFS1; NDUFB9; NDUFB6; NDUFA10; NDUFA9; GSN; ATP

FITC: Fluorescein Isothiocyanate

Polyclonal Antibody

WB

Affinity Purified

SDHB is supported by BioGPS gene expression data to be expressed in Jurkat

0.5 mg/ml

Cow: 100%; Dog: 100%; Goat: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 79%; Zebrafish: 86%

Liquid. Purified antibody supplied in 1x PBS buffer.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

31kDa

Cascon, A., (2008) J. Med. Genet. 45 (4), 233-238

Wet Ice

280

SDHB

SDHB

Rabbit

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

NM_003000

YRWMIDSRDDFTEERLAKLQDPFSLYRCHTIMNCTRTCPKGLNPGKAIAE

Mitochondrial