SDHB Mouse Monoclonal Antibody [Kloon ID: LBI2A1]

Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. [provided by RefSeq, Jul 2008]

Carrier-free (BSA/glycerol-free) SDHB mouse monoclonal antibody, clone LBI2A1

CWS2; IP; MC2DN4; PGL4; SDH; SDH1; SDH2; SDHIP

Homo sapiens succinate dehydrogenase complex iron sulfur subunit B (SDHB), mRNA; nuclear gene for mitochondrial product.

6390

P21912

Unconjugated

Alzheimer's disease, Citrate cycle (TCA cycle), Huntington's disease, Metabolic pathways, Oxidative phosphorylation, Parkinson's disease

Alzheimer's disease, Citrate cycle (TCA cycle), Huntington's disease, Metabolic pathways, Oxidative phosphorylation, Parkinson's disease

WB 1:500, IHC 1:150

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Lyophilized powder (original buffer 1X PBS, pH 7.3, 8% trehalose)

Druggable Genome

Stable for 1 year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. Aliquot will be stable at 4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

SDHB

https://www.ncbi.nlm.nih.gov/gene/?term=6390

https://www.uniprot.org/uniprot/P21912