SDHD Antilichaam

SDHD Antibody: The mitochondrial succinate dehydrogenase complex subunit D (SDHD) is one of four proteins that make up the tricarboxylic cycle enzyme succinate dehydrogenase (SCH) . Studies have shown that mutations in SDHD often leads to hereditary paragangliomas, usually benign tumors of the autonomic nervous system, suggesting that SDHD also plays a role as a tumor-suppressor gene. In one family with a nonsense mutation (R22X) in the SDHD gene, a loss of heterozygosity was found in the paragangliomas, and within these tumors the enzymatic activity of Complex II in the mitochondrial respiratory chain was completely abolished. Furthermore, high levels of angiogenic factors EPAS1 and VEGF was observed, which may stimulate tumor growth.

9392

O14521

NP_002993

Human, Mouse, Rat

Unconjugated

Primary Antibodies

Cancer, Cell Cycle

SDHD Antibody is affinity chromatography purified via peptide column.

Cat. No. 1287 - EL4 Cell Lysate

1 mg/mL

Predicted species reactivity based on immunogen sequence: Bovine: (100%), Sheep: (100%), Pig: (80%)

SDHD Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

SDHD antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

IgG

At least four isoforms of SDHD are known to exist; this antibody will detect the two longest isoforms.

SDHD

Cat. No. 17-207 - EL4 Cell Slide

Succinate dehydrogenase complex, subunit D, integral membrane protein

Homo sapiens

Baysal BE, Ferrell RE, Willett-Brozick JE, et al. Mutations in SDHD, a mitochondrial complex II gene, in hereditary paraganglioma. Science 2000; 287:848-51.

Saraste M. Oxidative phosphorylation at the fin de siecle. Science 1999; 283:1488-93.

Knudson AG. Genetics of human cancer. Annu. Rev. Genet. 1986; 20:231-51.

Gimenez-Roqueplo AP, Favier J, Rustin P, et al. The R22X mutation of the SDHD gene in hereditary paraganglioma abolishes the enzymatic activity of Complex II in the mitochondrial respiratory chain and activates the hypoxia pathway. Am. J. Hum. Genet. 2001; 69:1186-97.

SDHD Antibody: TRAP1, TRAP-1, SDH4, CII-4, CybS

ELISA, WB, ICC, IF

4506865

Liquid