SDPR Antilichaam

SDPR Antibody: The serum deprivation-response protein (SDPR) is a calcium-independent phospholipid-binding protein whose expression is increased in serum-starved cells. SDPR is a substrate for protein kinase C (PKC) phosphorylation and recruits the polymerase I and transcript release factor (PTRF) to caveolae. Removal of this protein causes caveolae loss and its over-expression results in caveolae deformation and membrane tubulation. Both SDPR and PTRF, as well as the other member of the cavin family PRKCDBP were down regulated in breast cancer cell lines and breast tumor tissue, suggesting that expression of the cavin family proteins could be a useful prognostic indicator of breast cancer progression.

8436

O95810

NP_004648

Human

Unconjugated

Primary Antibodies

Cancer, Cell Cycle

SDPR Antibody is affinity chromatography purified via peptide column.

Cat. No. 1201 - HeLa Cell Lysate

1 mg/mL

SDPR Antibody is supplied in PBS containing 0.02% sodium azide.

None

Blue Ice

SDPR antibody can be stored at 4˚ C for three months and -20˚ C, stable for up to one year.

IgG

It is predicted to not cross-react with other members of the cavin family.

SDPR

Cat. No. 10-901 - Human Spleen Tissue Slide

Serum deprivation response

Homo sapiens

Gustincich S, Vatta P, Goruppi S, et al. The human serum deprivation response gene (SDPR) maps to 2q32-q33 and codes for a phosphatidylserine-binding protein. Genomics 1999; 57:120-9.

Hansen CG, Bright NA, Howard G, et al. SDPR induces membrane curvature and functions in the formation of caveolae. Nat. Cell Biol. 2009; 11:807-14.

Bai L, Deng X, Li Q, et al. Down-regulation of the cavin family proteins in breast cancer. J. Cell Biochem. 2012; 113:322-8.

SDPR Antibody: SDR, CAVIN2, PS-p68, cavin-2, Serum deprivation-response protein, Cavin-2

ELISA, WB, IHC-P, IF

4759082

Liquid