SECISBP2 (NM 024077) Humaan Recombinant Proteïne

The protein encoded by this gene is one of the essential components of the machinery involved in co-translational insertion of selenocysteine (Sec) into selenoproteins. Sec is encoded by the UGA codon, which normally signals translation termination. The recoding of UGA as Sec codon requires a Sec insertion sequence (SECIS) element; present in the 3' untranslated regions of eukaryotic selenoprotein mRNAs. This protein specifically binds to the SECIS element, which is stimulated by a Sec-specific translation elongation factor. Mutations in this gene have been associated with reduction in enzymatic activity of type II iodothyronine deiodinase (a selenoprotein) and abnormal thyroid hormone metabolism. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2017]

Purified recombinant protein of Human SECIS binding protein 2 (SECISBP2), Met1-Gln101, with N-terminal His-PDCD1 (Pro21-Val170) tag, expressed in E. coli, 50ug

SBP2

79048

Q96T21

NM_024077

9q22.2

E. coli

N-terminal His-PDCD1 (Pro21-Val170) tag

>50 ug/mL as determined by microplate BCA method

> 80% as determined by SDS-PAGE and Coomassie blue staining

Liquid

50mM Tris, 8M Urea, pH8.0

27.9 kDa

Stable for 1 year at -20°C or below from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and opening the cap. For long-term storage, aliquot and store at -20°C or below. Avoid repeated freeze-thaw cycles.

SECISBP2

Human

NP_076982

https://www.ncbi.nlm.nih.gov/gene/79048

https://www.uniprot.org/uniprot/Q96T21

https://www.ncbi.nlm.nih.gov/nuccore/NM_024077

https://www.ncbi.nlm.nih.gov/nuccore/NP_076982