(-) -Securinine (nitraat)

(-) -Securinine (nitrate) is plant-derived alkaloid and also a GABAA receptor antagonist[1][2].

7104-26-9

12352005

GABA Receptor

Membrane Transporter/Ion Channel; Neuronal Signaling

Cancer; Neurological Disease

O=C(O1)C=C2[C@@]13[C@](CCCC4)([H])N4[C@](C3)([H])C=C2.O[N+]([O-])=O

C13H16N2O5

280.28

[1]Stefanowicz-Hajduk J, et al. Securinine from Phyllanthus glaucus Induces Cell Cycle Arrest and Apoptosis in Human Cervical Cancer HeLa Cells. PLoS One. 2016 Oct 28;11 (10) :e0165372. |[2]Kalpana Gupta, et al. Securinine, a Myeloid Differentiation Agent with Therapeutic Potential for AML. PLoS One. 2011; 6 (6) : e21203.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N2079A/

Reference compound1

No Development Reported