SELENOS Antilichaam - middengebied HRP (ARP48082 P050-HRP)

Selenoprotein S

SELS, VIMP, ADO15, SBBI8, SEPS1, AD-015

55829

Q9BQE4

NP_060915

Human, Mouse, Rat, Cow, Dog, Goat, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish

The immunogen is a synthetic peptide directed towards the middle region of human SELS

This gene encodes a transmembrane protein that is localized in the endoplasmic reticulum (ER) . It is involved in the degradation process of misfolded proteins in the ER, and may also have a role in inflammation control. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) . Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Two additional phylogenetically conserved stem-loop structures (Stem-loop 1 and Stem-loop 2) in the 3' UTR of this mRNA have been shown to function as modulators of Sec insertion. An alternatively spliced transcript variant, lacking the SECIS element and encoding a non-Sec containing shorter isoform, has been described for this gene (PMID:23614019) .

UBC; SRPK2; PTGS2; CAV1; DERL2; APOB; DERL1; VCP; KPNB1; AMFR; SYVN1; HERPUD1; SAA1; SVIP; NPLOC4; UFD1L; HSPA4

HRP: Horseradish Peroxidase

Polyclonal Antibody

WB

Affinity Purified

0.5 mg/ml

Cow: 93%; Dog: 86%; Goat: 75%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 93%; Rabbit: 92%; Rat: 93%; Yeast: 90%; Zebrafish: 100%

Liquid. Purified antibody is supplied in high phosphate PBS, 100 mm phosphate, 150 mM NaCl, pH 7.6.

All conjugated antibodies should be stored in light-protected vials or covered with a light protecting material (i.e. aluminum foil) . Conjugated antibodies are stable for at least 12 months at 4C. If longer storage is desired (24 months), conjugates may be diluted with up to 50% glycerol and stored at -20C to -80C. Freezing and thawing conjugated antibodies will compromise enzyme activity as well as antibody binding.

21kDa

Moses, E.K., Am. J. Obstet. Gynecol. 198 (3), 336 (2008)

Wet Ice

189

SELENOS

SELENOS

Rabbit

Selenoprotein S

NM_018445

PDVVVKRQEALAAARLKMQEELNAQVEKHKEKLKQLEEEKRRQKIEMWDS