SELPLG-antilichaam

This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.

6404

Q14242

Human

Recombinant fusion protein containing a sequence corresponding to amino acids 40-280 of human SELPLG (NP_002997.1) .

Unconjugated

Primary Antibodies

Cell Cycle, Immunology

Affinity purification

DU145

Batch dependent

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

None

Blue Ice

Store at -20˚ C. Avoid freeze / thaw cycles.

Observed: 52kDa

IgG

WB: 1:500 - 1:2000

SELPLG

Jurkat

U-937

Selectin P ligand

Homo sapiens

P-selectin glycoprotein ligand 1, PSGL-1, Selectin P ligand, CD162, SELPLG

WB

Liquid