Semaforine 4D / SEMA4D / CD100 eiwit (ECD, zijn tag)

Semaphorin 4D (SEMA4D or CD100) is a member of the semaphorin family of proteins and an important mediator of the movement and differentiation of multiple cell types, including those of the immune, vascular, and nervous systems. VEGF and SEMA4D had a positive correlation with the malignant degree of ovarian cancer, and SEMA4D can serve as an independent prognostic factor. SEMA4D was the first semaphorin described to have immune functions and serves important roles in T cell priming, antibody production, and cell-to-cell adhesion. Proteolytic cleavage of SEMA4D from the cell surface gives rise to a soluble fragment of SEMA4D (sSEMA4D) . Similar to the transmembranal form, sSEMA4D is thought to have immunoregulatory properties.

CD100 Protein; coll-4 Protein; Sema4d Protein; Semacl2 Protein; Semaj Protein; Semcl2 Protein

NP_038688.2

Mouse

Mouse

His-Tag

See Datasheet send with the product

< 1.0 EU per μg of the protein as determined by the LAL method

≥ 96 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC.

Measured by its ability to bind human SEMA4A in a functional ELISA.

721

Lyophilized or frozen liquid

PBS, pH 7.4

See Datasheet

110 kDa (glycosylated)

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

HEK 293 cells