Semaforine 4D / SEMA4D / CD100 eiwit (Zijn tag)

Semaphorin 4D (SEMA4D or CD100) is a member of the semaphorin family of proteins and an important mediator of the movement and differentiation of multiple cell types, including those of the immune, vascular, and nervous systems. VEGF and SEMA4D had a positive correlation with the malignant degree of ovarian cancer, and SEMA4D can serve as an independent prognostic factor. SEMA4D was the first semaphorin described to have immune functions and serves important roles in T cell priming, antibody production, and cell-to-cell adhesion. Proteolytic cleavage of SEMA4D from the cell surface gives rise to a soluble fragment of SEMA4D (sSEMA4D) . Similar to the transmembranal form, sSEMA4D is thought to have immunoregulatory properties.

A8 Protein; BB18 Protein; C9orf164 Protein; CD100 Protein; coll-4 Protein; COLL4 Protein; FLJ39737 Protein; GR3 Protein; M-sema-G Protein; SEMAJ Protein

AAH54500.1

Human

Human

His-Tag

See Datasheet send with the product

< 1.0 EU per μg of the protein as determined by the LAL method

> 92 % as determined by SDS-PAGE

Measured by its ability to bind mouse CD45 hFc in functional ELISA.

725

Lyophilized or frozen liquid

PBS, pH 7.4

See Datasheet

110 kDa (glycosylated)

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

HEK 293 cells