SEN 78702
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
SEN 78702 is an orally active, selective, full α7 nAChR agonist, with a pEC50 of 6.13. SEN 78702 has an acceptable hERG inhibition (IC50: 15.8 μM) . SEN 78702 induces memory enhancement[1].
1205530-63-7
12352005
NAChR; Potassium Channel
Membrane Transporter/Ion Channel; Neuronal Signaling
Neurological Disease
O=C(NC1=CC(C2=CC(F)=CN=C2)=NN1)CCCN3CCCCC3
C17H22FN5O
331.39
[1]Zanaletti R, et al. N-[5- (5-Fluoropyridin-3-yl) -1 H-pyrazol-3-yl]-4-piperidin-1-ylbutyramide (SEN78702, WYE-308775) : A Medicinal Chemistry Effort toward an α7 Nicotinic Acetylcholine Receptor Agonist Preclinical Candidate[J]. Journal of Medicinal Chemistry, 2012, 55 (22) : 10277-10281.
Room temperature
http://file.medchemexpress.com/batch_PDF/HY-18176/
Reference compound1
No Development Reported
Beschrijving
SEN 78702 is an orally active, selective, full α7 nAChR agonist, with a pEC50 of 6.13. SEN 78702 has an acceptable hERG inhibition (IC50: 15.8 μM) . SEN 78702 i
Specificaties
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