Senexin B
Kwaliteit
ISO Gecertificeerd
Levering
24-48 uur
Technische Specificaties
Senexin B is a potent inhibitor of cyclin-dependent kinases 8 and 19.1 It suppressed tumor growth and augmented the effects of fulvestrant in ER-positive breast cancer xenografts. KD50s: CDK8 = 59 nM, CDK19 = 23 nM.2 Senexin B also showed synergistic effects with lapatinib and trastuzumab in a panel of HER2+ breast cancer cell lines. Senexin B and ALK5 inhibitor SB431542 afforded generation of pancreatic islet cells from pluripotent stem cells without any mutagenic effects.4 Combination treatment of Senexin B and Imatinib intensified apoptotic cell death in chronic myelogenous leukemia cells and prevented quiescence-mediated escape from apoptosis.5
Unconjugated
Off-white solid
-20°C
Beschrijving
Senexin B Beschikbaar in 5 mg. Bestel eenvoudig online met snelle levering.
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