Sennoside

Sennoside is an orally active anthraquinone glycoside that can be used as a stimulant laxative. Sennoside exerts prokinetic and secretory effects via activation of 5-HT4 receptors in the myenteric plexus and inhibition of Na+/K+-ATPase activity. Sennoside is promising for research of chronic constipation[1].

517-43-1

12352005

H317-H334

5-HT Receptor; Na+/K+ ATPase

GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

Metabolism-protein/nucleotide metabolism

Metabolic Disease

OC[C@@H](O1)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC2=CC=CC3=C2C(C4=C(C=C(C(O)=O)C=C4O)C3C5C6=C(C(C7=C5C=C(C(O)=O)C=C7O)=O)C(O[C@H]8[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O8)=CC=C6)=O

C42H38O20

862.74

P261-P272-P280-P284-P302+P352-P304+P340-P362+P364-P501

[1]Rama Reddy NR, et al. Next Generation Sequencing and Transcriptome Analysis Predicts Biosynthetic Pathway of Sennosides from Senna (Cassia angustifolia Vahl.), a Non-Model Plant with Potent Laxative Properties. PLoS One. 2015 Jun 22;10 (6) :e0129422.

Room temperature

http://file.medchemexpress.com/batch_PDF/HY-N12281/

Natural Products

Phase 2